As colonoscopy is widely used as a diagnostic tool in Korea, it produces many complications such as colonic bleeding and perforation. These are considered to be an usual event, not as a concept of complication. Therefore, the adverse events are given the term of incidental events, not as the complications in the recent days. Medical treatment may be offered as an alternative to surgical method for immediate management of these complications. Colonic perforation usually results in fatal and emergent condition requiring surgical intervention. Others described the application of endoclip as a therapeutic endoscopic maneuver twenty years ago, and in 1997, Yoshikane et al. used clips to close a colonic perforation after performing the endoscopic mucosal resection of an early cancer. Since then, endoscopic repairs of iatrogenic perforation have frequently been used in many cases. We report a 69 year-old man who was successfully treated by endoscopic clipping of iatrogenic colonic perforation site during polypectomy without complications.