Journal Browser Advanced Search Help
Journal Browser Advanced search HELP
Korean J Gastrointest Endosc. 2005 Mar;30(3):133-139. Korean. Original Article.
Kim SH , Jung JH , Kang YS , Kim YS , Park KO , Lee YS , Kim SM , Seo SW , Seong JK , Lee BS , Jeong HY , Song GS .
Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea. Jeonghy@cnuh.co.kr
Department of Pathology, Chungnam National University College of Medicine, Daejeon, Korea.
Abstract

BACKGROUND/AIMS: The aim of this study was to investigate the value of expression of COX-2 and p53 protein in colonic adenoma with or without malignant change. METHODS: We studied twenty-five cases of colonic adenoma with malignant change and twenty-five cases of colonic adenoma without malignant change treated by colonoscopic polypectomy in Chungnam National University Hospital from January, 1999 to July, 2002. We compared the expression of COX-2 and p53 protein by immunohistochemical stain in both group. RESULTS: In immunohistochemical staining, the expression of COX-2 was demonstrated 68.0% (17 of 25) of colonic adenoma with malignant change and not different with that of colonic adenoma without malignant change. The overexpression of p53 protein was detected immunohistochemically in 88.0% (22 of 25) of colonic adenoma with malignant change and 32% (8 of 25) of colonic adenoma only (p <0.05). CONCLUSIONS: The degree of COX-2 expression was similar in colonic adenoma and colonic adenoma with malignant change, but the expression of p53 in colonic adenoma with malignant change was significantly higher (p <0.05). These results suggest COX-2 might operate on early step of adenoma-carcinoma sequence. Also these results remind us that mutation of p53 gene operates on the late step of adenoma-carcinoma sequence.

Copyright © 2019. Korean Association of Medical Journal Editors.