Pyogenic granuloma (PG) is a polypoid form of capillary hemangioma occurring on the skin and mucosal surfaces. The well-established lesion is a rapidly growing, polypoid, friable, purple- red mass that bleeds easily and frequently ulcerates. Microscopically, it is composed of small blood vessels arranged in a distinctive lobular pattern with or without ulceration of the surfaces. Except for the oral cavity, this lesion is extremely rare in the gastrointestinal tract and up to the present, about 26 cases of gastrointestinal PG have been reported. Of them, 21 cases were reported from East Asia, Japan, Korea, and Taipei. The most common presenting sign of gastrointestinal PG was tarry stool and anemia. In most cases, lesion was solitary, and revealed a protruded and/or pedunculated growth pattern with superficial erosions. We have recently experienced a case of pyogenic granuloma in the terminal ileum and successfully treated by endoscopic snare polypectomy.