The Peutz-Jeghers syndrome is an autosomal dominant disease characterized by mucocutaneous pigmentation and gastrointestinal hamartomatous polyps. This syndrome is clinically important because of the complications caused by polyps and of an increased risk of cancer. We experienced a typical case of Peutz-Jeghers syndrome in a 24-year-old female patient who presented with jejunojejunal intussusception. With the use of combined surgery and intraoperative endoscopy through trocar, 60 polyps were removed, performing only 2 enterotomies. We apply a modified endosocopic technique of intraoperative endoscopic resection of small-bowel polyps using conventional 10 mm metal trocar in conjunction with a corrugated anesthetic tube. This allows fully visualized and optically controlled removal of all small intestnal polyps without air leakage. The usefulness of this technique reduces the complications associated with multiple laparotomies and resections.