Non-typhoidal salmonella (NTS) is a common pathogen involved in food poisoning. It has various extraintestinal complications including encephalopathy. However, NTS associated encephalopathy is rarely reported. A previously healthy 14-year-old boy was admitted for altered level of consciousness. He had profuse watery diarrhea with fever on the day of admission. Physical examination was unremarkable except slightly increased bowel sounds and altered mental state. Cerebrospinal fluid analysis revealed mild pleocytosis. Meningoencephalitis was the presumptive diagnosis. His consciousness was recovered over 24 hours, bloody and mucoid diarrhea developed the next day after admission. NTS organism was isolated from his stool. After 1 week, he fully recovered neurologically but a mild watery diarrhea persisted at the time of discharge.