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J Korean Child Neurol Soc. 2006 Nov;14(2):358-362. Korean. Case Report.
Kook DH , Cho SY , Lee KY , Lee IG , Lee JS .
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Acute isoniazid overdose is a relatively uncommon but potentially life-threatening event. Isoniazid overdose should be suspected in any patient with repeated seizures, coma and metabolic acidosis of uncertain etiology. The effective antidote for acute isoniazid- induced neurotoxicity is known to be pyridoxine. We report a 4-month old boy who showed repeated seizures, coma, metabolic acidosis and hyperglycemia from an accidental isoniazid overdose(100 mg/kg). This boy was recovered completely by the pyridoxine treatment with a dose of equivalent to the amount of isoniazid ingested.

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