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Korean J Cytopathol. 1999 Dec;10(2):121-126. Korean. Original Article.
Lim SJ , Kim GY , Kim YW , Park YK , Lee J , Yang MH , Won NH .
Department of Pathology, College of Medicine, Kyung Hee University, , Seoul, Korea. Leejuhie@chollian.net
Abstract

The usefulness of E-cadherin immunostaining as a marker of malignancy in the body fluids was investigated in the present study. Thirty-three histologically proven cases of cell blocks from the pleural, peritoneal, and pericardial fluids were studied by immunocytochemistry for E-cadherin antibody using LSAB method. These cases were cytologically diagnosed as adenocarcinoma (25 cases) and atypical cells (8 cases). Tumor cells showed strong positive membranous staining for E-cadherin antibody in 21 out of 25 cases (84%) of adenocarcinoma. E-cadherin staining was not found in 6 of 8 cases of suspicious maligancy. The sensitivity and specificity were 84% and 75%, respectively. Reactive mesothelial cells and inflammatory cells scattered were all negative. In conclusion, E-cadherin is an useful adjunctive marker to distinguish reactive mesothelial cells from the carcinoma cells in the body fluids.

Copyright © 2019. Korean Association of Medical Journal Editors.