It Is generally accepted that autografts of bone are superior to any other types of bone graft. But this technique may be hampered by the size of the bone defect and requires additional surgical procedure, therefore results in increased risk of infection and morbidity. Recently, there is increasing interest in autogenous bone substitute and biomaterials which being extensively investigated: coral, ceramic implants and xenograft can be used as bone substitutes. Some authors have reported successful results using bovine cancellous bone graft in experimental and clinical studies. Authors experienced 15 cases augmentation of cleft lip nose deformity of hypoplastic pyriform rim and maxillary alveolus by using Lubboc(R)(purified bovine cancellous bone matrix) including 3 failure cases of autogenous bone graft. The patient's follow-up period ranged from 4 months to 30 months. In our series, we found no adverse immune reaction and experienced favorable aesthetic results in augmentation of alar base with maintenence of considerable volume and stability. Through long term follow-up, this new purified bovine cancellous bone can be a reliable bone substitute in the treatment of minor bone defect.