In order to investigate industrial fatigue of pharmacists, the questionnaire survey for subjective symptoms and its related factors was carried out on 435 pharmacists who were managing pharmacies in Seoul. The Questionnaires were composed of three groups of 10 items each, representing dullness and sleepness(I), difficulty in concentrations (II) and bodily projection of fatigue (III). The results were as follows : 1. The complaint rate of fatigue was the highest in 'eye strain' and followed by 'whole body tires', 'apt to forget', 'leg feel heavy', 'feel drowsy' and 'feel like tying' in the descending order. 2. The average weighted score of fatigue complaint was the highest in dullness and sleepness group(I) and followed by difficulty in concentrations group(II) and bodily projection of fatigue group(III) in the descending order, suggesting the heavier mental stress rattier than physical burden of the pharmacists work contents. 3. The average weighted scores of fatigue complaints were significantly higher in female and 0-3 off-duty days per month group than those in male and more than 4 off-duty days per month group. 4. The average weighted scores of fatigue complaints were significantly different among the characteristic groups of counselling postures, noise and using chairs. 5. The groups with the high quality of sleeping, regular physical exercise and diet, or satisfied with their job and income had significantly lower average weighted scores of fatigue complaints. 6. The 42.5% of the subjects complained feeling heavy chronic fatigue. And the significant differences for average weighted scorns were noted among three groups, representing 26.64 in feeling heavy chronic fatigue, 18.23 in feeling light chronic fatigue, and 9.50 in feeling no chronic fatigue.