There are frequently limitations to general wound dressing in some cases. Dermabond(R) has been available as a skin closure alternative. The purpose of this study was to apply this topical skin adhesive in postoperative wound management. Dermabond(R) was used for postoperative dressing in total 62 cases; group A includes wounds of the perineum & anus, which have greater chance of contamination(N=16), group B includes wounds located in hairy areas, which are difficult to cover up (N=21), group C includes wounds in children or bed-ridden patients, who have poor compliance (N=6), and group D includes wounds in patients who underwent free flap operations(N=19). There were no infections in group A by separating the wounds from infection sources. Dressings in group B were done much more simply and comfortable. There was increased compliance of patients in group C, as patients could wash around the wound. It was possible to carry out real time monitoring in group D as the simply coverage of the wound. Using Dermabond(R) after primary closure was found to be efficient in the management of wounds near areas with greater chance of being contaminated, wounds which are hard to cover up with dressing materials, wounds in patients with poor compliance, and wounds requiring frequent observation.