Takayasu's arteritis (TA) is an uncommon, chronic inflammatory disease of elastic arteries such as the aorta, its larger branches and the pulmonary artery trunk, and develops into an obstructive process. Antiphospholipid syndrome (APS) is characterized by obstetric and thrombotic complications in the presence of antiphospholipid antibodies. It can happen in an isolated way or in association with connective tissue diseases, mainly systemic lupus erythematosus (SLE). The association of APS and SLE with TA is rarely described in the foreign reports, but not yet in Korea. We described a case of TA in a patient with APS secondary to SLE.