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J Korean Rheum Assoc. 2008 Jun;15(2):118-122. Korean. Original Article. https://doi.org/10.4078/jkra.2008.15.2.118
Baek SH , Lee JH , Kim GT , Lee JW , Cho MR , Kim JI , Lee SH , Kim DS , Kim SI .
Department of Internal Medicine, College of Medicine, Pusan National University, Busan, Korea. ksimd@pusan.ac.kr
Department of Neurology, College of Medicine, Pusan National University, Busan, Korea.
Research Institute, College of Medicine, Pusan National University, Busan, Korea.
Department of Internal Medicine, Busan St. Mary's Medical Center, Busan, Korea.
Abstract

OBJECTIVE: Idiopathic inflammatory myopathies (IIMs) are systemic autoimmune diseases characterized by infiltration of T lymphocytes, monocytes, and macrophages in muscle tissues. Interleukin-17 (IL-17), a Th17 cytokine, has potent pro-inflammatory actions and plays a role in autoimmune diseases. We investigated the expression of IL-17 in muscle tissues of patients with IIMs. METHODS: We measured the IL-17 mRNA level of muscle tissues from 14 patients with IIMs (9 patients with dermatomyositis and 5 patients with polymyositis) by real-time RT-PCR and compared with controls. We also performed an immunohistochemical stain to detect IL-17 expression. RESULTS: The expressions of IL-17 were significantly enhanced in IIMs than controls. In immunohistochemistry, IL-17 was expressed in perimysial, endomysial and perivascular infiltrating inflammatory cells. CONCLUSION: These results suggest that IL-17 plays a role in the immunopathogenesis of IIMs.

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