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J Korean Rheum Assoc. 2008 Mar;15(1):1-10. Korean. Review.
Im GI .
Department of Orthopaedics, DongGuk University International Hospital, Dongguk University College of Medicine, Seoul, Korea.

Osteoblastic differentiations of mesenchymal stem cells are controlled by a number of intracellular signal transduction systems and transcription factors. These systems and factors interacts with and cross-talks to one another to complete the process of bone formation. Discovery of these systems has been enabled by gene-targeting techniques. In this brief review, the signal transduction pathways and transcription factors of importance to osteoblastic differentiation are introduced.

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