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J Korean Rheum Assoc. 2006 Mar;13(1):82-85. Korean. Case Report.
Park JR , Rho YH , Choi SJ , Im GJ , Jung HH , Lee YH , Ji JD , Song GG .
Division of Rheumatology, Korea University Anam Hospital, Seoul, Korea.
Department of Otolaryngology, Korea University Anam Hospital, Seoul, Korea.

Cogan's syndrome is a rare chronic inflammatory disease of unknown origin, characterized by nonsyphilitic interstitial keratitis, vestibuloauditory dysfunction and vasculitis. Cogan's syndrome is uncommon and few cases have been published. A case of Cogan's syndrome in a patient with anti-Ro and anti-La positivity is described. A 24-year-old woman visited to department of rheumatology with dry mouth, dry eye, and vertigo on August 2004, and interstitial keratitis had developed on October 2004. She was admitted to the otolaryngology department with rapidly progressive hearing loss on December 2004. The patient's audiogram revealed severe sensorineural deafness. The patient was treated with systemic corticosteroid and methotrexate. This case is the first to report a case of Cogan's syndrome associated with anti-Ro and anti-La positivity.

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