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J Korean Rheum Assoc. 2005 Jun;12(2):108-115. Korean. Original Article.
Song JK , Shin HY , Lee YS , Hwang JH , Kwon YS , Jeong YJ , Lee YJ , Kang SW .
Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea. kangsw@cnuh.co.kr
Department of Radiology, Seoul Municipal Dong-bu Hospital, Seoul, Korea.
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Abstract

OBJECTIVE: Rheumatoid arthritis (RA) is characterized by the interaction of multiple mediators, especially cytokines. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine and has been shown to be involved in RA. This study explored the association of the MIF gene polymorphism with RA in Korean. METHODS: 114 patients with RA, and 114 age and gender matched healthy controls were studied. Patients and controls were genotyped for a single nucleotide polymorphism (SNP) in the 5'-flanking region at position -173 of the MIF gene. RESULTS: No significant differences in MIF gene polymorphism were observed in RA compared to healthy controls. No association with disease severity was detected for the MIF gene polymorphism. CONCLUSION: MIF -173 G/C polymorphism did not appear to be associated with genetic susceptibility and disease severity in Korean RA patients.

Copyright © 2019. Korean Association of Medical Journal Editors.