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J Korean Rheum Assoc. 2001 Sep;8(3):203-207. Korean. Case Report.
Ryu SH , Yun JH , Jung WT , Park EH , Kwon HC , Lee SW , Chung WT .
Department of Internal Medicine, College of Medicine, Dong-A University, Pusan, Korea.

Cryoglobulins are cold-precipitable monoclonal or polyclonal immunoglobulins,which can occur without an identifiable underlying disease condition or in association with underlying disorders.Cryoglobulinemic vasculitis is immune complex-mediated vasculitis that predominantly affect small vessels.Less often,medium-sized or even large vessels can be affected.Cryoglobulinemic vasculitis is a rare one of the cutaneous manifestations of multiple myeloma.We experienced a patient with cryoglobulinemic vasculitis developed in multiple myeloma who presented with Raynaud's phenomenon,purpuric patch and skin ulcer.

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