A malignant fibrous histiocytoma (MFH) is one of the most common types of soft-tissue sarcomas. It tends to develop in elderly people and is mainly localized in skeletal muscles, the dermis, the subcutis, and the retroperitoneum. A MFH of the intestine is an exceedingly rare neoplasm. We experienced a primary inflammatory malignant fibrous histiocytoma of the colon in a 51-year-old male. A right hemicolectomy and gastro-jejunostomy were performed. Microscopically, the tumor consisted of atypical fibroblast like spindle cells, arranged in a storiform or fascicular pattern and accompanied by infiltration of acute inflammatory cells.