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J Korean Endocr Soc. 2008 Dec;23(6):444-449. Korean. Case Report. https://doi.org/10.3803/jkes.2008.23.6.444
Jeong HS , Kang JY , Kim H , Lee KH , Lee DS , Choi GY , Oh TG , Jeon HJ .
Department of Internal Medicine, Chungbuk National University College of Medicine, Korea.
Abstract

MELAS (mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes) syndrome is characterized by stroke-like episodes before the age of 40, encephalopathy, seizures, dementia and lactic acidosis, and is caused by mutations in mitochondrial DNA. Diabetes mellitus and cardiac involvement are also frequently seen in MELAS syndrome. It is a classic mitochondrial disorder that shows a slow, chronic, progressive course, and presents with multiple organ involvement including the central nervous system, skeletal muscle, eye, cardiac muscle and gastrointestinal system.

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