Generalized or localized edema is a very common symptom in primary care. Edema is developed from an imbalance in the filtration system between the vessel and interstitial spaces. A systematic approach is extremely important to determine the underlying diagnosis, because its management plan depends on the cause of edema. Treatment includes sodium restriction, diuretic use, appropriate management of the underlying disorder, et al. This review can be helpful in establishing the management of edema in clinical practice.