Clin Orthop Surg.  2009 Dec;1(4):240-243. 10.4055/cios.2009.1.4.240.

Low Grade Fibromyxoid Sarcoma in Thigh

• Lee BJ
• Park WS
• Jin JM
• Ha CW
• Lee SH

• KMID: 999408
• DOI: http://doi.org/10.4055/cios.2009.1.4.240

Abstract

A low grade fibromyxoid sarcoma is a rare soft tissue tumor that has a tendency to develop in the deep soft tissue of young adults and the potential for local recurrence or distant metastasis. There have been several case reports and sporadic reports in the literature. However, only 1 case has been reported in Korea but without a follow-up result. We describe a 54-year-old female patient with a low-grade fibromyxoid sarcoma of the thigh that had been growing slowly for 34 years. A marginal resection of this tumor was performed. Currently, the patient is doing well without evidence of local recurrence or distant metastasis at 5 years after surgery.

Keyword

Low grade fibromyxoid sarcoma; Thigh

MeSH Terms

Female
Fibrosarcoma/*pathology/surgery
Humans
Middle Aged
Soft Tissue Neoplasms/*pathology/surgery
Thigh/*pathology/surgery

Figure

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  Fig. 1 On MRI, the tumor is a 17 × 11 × 9 cm sized mass located under the quadriceps muscle. The tumor matrix is partially calcified and relatively well defined one having irregular low signal intensity in the T1 weighted image (A) and heterogeneous low signal and high signal in the T2 weighted image (B-D).

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  Fig. 2 Optical microscopy examination demonstrates a mass with sharp demarcation, nodular growth pattern and intervening hypocellular collagenous stroma (A: Hematoxylin and eosin stain, ×100). The tumor shows a biphasic pattern with fibrous and myxoid areas, minimal nuclear pleomorphism, low to moderate cellularity, and a swirling, whorled growth (B: Hematoxylin and eosin stain, ×200). The background matrix ranges from fibromyxoid to densely fibrous (C: Hematoxylin and eosin stain, ×400). Immunohistochemically, the tumor cells are diffusely and strongly positive for vimentin (D: Immunohistochemical stain for vimentin, ×1400).

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  Fig. 3 The patient is still alive with no evidence of local recurrence and distant metastasis five years after excision. The range of motion of the knee joint is full and the strength of the quadriceps muscle is normal.

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