Korean J Radiol.  2011 Feb;12(1):135-139. 10.3348/kjr.2011.12.1.135.

MR Imaging Findings of a Primary Cardiac Osteosarcoma and Its Bone Metastasis with Histopathologic Correlation

• Ahn S
• Choi JA
• Chung JH
• Choi H
• Chun EJ
• Choi SI
• Kang HS

• KMID: 991692
• DOI: http://doi.org/10.3348/kjr.2011.12.1.135

Abstract

An osteosarcoma of cardiac origin is extremely rare, and a comprehensive description of MR imaging (MRI) findings of cardiac osteosarcoma and its metastasis in the femur have not been reported in the literature. We present a case of cardiac osteosarcoma in a 47-year-old woman and its metastasis to the femur, focusing on the description of MRI findings of the cardiac and metastatic bony osteosarcoma with a histopathologic correlation.

Keyword

Bone neoplasms; Bone neoplasms, diagnosis; Bone neoplasms, metastasis; Bone neoplasms, MR; Neoplasms, heart

MeSH Terms

Female
Femoral Neoplasms/pathology/*secondary
Heart Neoplasms/*diagnosis/pathology
Humans
*Magnetic Resonance Imaging
Middle Aged
Osteosarcoma/*diagnosis/pathology/*secondary

Figure

• 

  Fig. 1 MRI and histologic finding of cardiac osteosarcoma and its femoral metastasis. A. Axial double inversion-recovery T1-weighted image with fat saturation (TR/TE, 960/8.6 msec) showed well-demarcated mass of mildly heterogeneous and high signal intensity without evidence of invasion into surrounding structures. B, C. Axial triple inversion-recovery T2-weighted image with fat saturation (TR/TE, 960/100 msec) and four chamber view of cine image (3211/1605 msec) showed heterogeneous signal intensity of mass. D. Axial image of delayed contrast-enhanced MRI (TR/TE, 4457/1427 msec) showed heterogeneous enhancement. E. Mass measured about 5.0 × 3.7 × 2.3 cm and had focal hemorrhage and necrosis on gross specimen. F. Photomicrograph showed atypical spindle cells with abundant collagen material and displayed focal immature osteoid production (Hematoxylin & Eosin stain, × 40). G. T1-weighted coronal image (TR/TE, 651/20 msec) showed mass that was isointense to muscle at right femoral neck. Peripheral rim with low signal intensity was seen. H. T2-weighted axial image (TR/TE, 4053/100 msec) showed heterogeneously high signal intensity lesion with peripheral hypointense rim at right femoral neck. I. Gadolinium-enhanced T1-weighted coronal image with fat suppression (TR/TE, 540/17 msec) was performed and lesion showed heterogeneous enhancement within central portion of non-enhancement. J. Atypical spindle cells with abundant collagen material were seen on photomicrograph (Hematoxylin & Eosin stain, × 40).

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