Korean J Radiol.  2000 Jun;1(2):114-117. 10.3348/kjr.2000.1.2.114.

Disseminated BCG Infection in a patient with Severe Combined Immunodeficiency

• Han TI
• Kim IO
• Kim WS
• Yeon KM

• KMID: 966483
• DOI: http://doi.org/10.3348/kjr.2000.1.2.114

Abstract

Disseminated mycobacterial infection after bacillus Calmette-Guerin (BCG)vaccination is a very rare disorder, occurring mostly in patients with immunologic deficiency. We report a case of disseminated BCG infection in a 16-month-old girl with severe combined immunodeficiency. Plain radiographs showed multiple osteolytic lesions in the femora, tibiae, humerus, and phalanges. Abdominal sonography and CT scanning revealed multiple nodules in the spleen, and porto-caval lymphadenopathy.

Keyword

Bones, infection; Infants, newborn, skeletal system; Tuberculosis, gastrointestinal; Tuberculosis, musculoskeletal

MeSH Terms

*BCG Vaccine
Case Report
Female
Human
Infant
Mycobacterium bovis
Severe Combined Immunodeficiency/*immunology
Tomography, X-Ray Computed
Tuberculosis/*immunology/radiography/ultrasonography

Figure

• 

  Fig. 1 Disseminated BCG infection in a 16-month-old girl with severe combined immunodeficiency. A. Plain radiograph of both lower extremities reveals multiple, round, osteolytic lesions in the distal femora, tibiae, and fibulas. Both tibiae show extensive periosteal thickening along the entire diaphyses. Osteolytic lesions extend into the thickened periosteum (arrows). B. Transverse sonogram through the upper abdomen shows enlarged lymph nodes containing eccentric hypoechoic portion (arrow) at the porta hepatis. C. Longitudinal us scan of the spleen reveals hypoechoic nodules (arrows). D. Contrast enhanced CT scan shows multiple, round, hypodense nodules in the spleen. The presence of portocaval lymphadenopathy, with a central low attenuated area (arrow), should also be noted.

Reference

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