J Korean Med Sci.  2000 Oct;15(5):585-588. 10.3346/jkms.2000.15.5.585.

Churg-Strauss syndrome with perforating ulcers of the colon

• Kim YB
• Choi SW
• Park IS
• Han JY
• Hur YS
• Chu YC

• KMID: 965883
• DOI: http://doi.org/10.3346/jkms.2000.15.5.585

Abstract

We report a case of a 72-year-old woman with Churg-Strauss syndrome, who presented with intestinal perforation. She has had bronchial asthma with peripheral blood eosinophilia for 30 years. Gross findings of a resected colon showed multiple ulcers with perforation. Histologic findings demonstrated transmural inflammation infiltrated with large numbers of eosionophils, neutrophils and lymphoplasma cells, and characteristic extravascular granuloma in the subserosa. There were multifocally-distributed transmural vasculitis showing all stages of activity in medium and small-sized arteries and veins located in the submucosa, and proper muscle and subserosal layers of the colon, some of which revealed granulomatous inflammation. Histologic finding of liver showed chronic viral hepatitis B with mild inflammatory activity and macronodular cirrhosis. Immunohistochemical findings, acid fuschin orange G staining and electromicroscope found no evidence of hepatitis B virus infection contributing to the pathogenesis of this lesion.

Keyword

Churg-Strauss Syndrome; Intestinal Perforation; Hepatitis B

MeSH Terms

Aged
Case Report
Churg-Strauss Syndrome/virology
Churg-Strauss Syndrome/pathology
Churg-Strauss Syndrome/complications*
Colon/virology
Colon/pathology*
Colonic Diseases/virology
Colonic Diseases/pathology
Colonic Diseases/etiology*
Female
Hepatitis B/pathology
Hepatitis B Antigens/analysis
Human
Immunohistochemistry
Intestinal Perforation/virology
Intestinal Perforation/pathology
Intestinal Perforation/etiology*