Korean J Gastroenterol.
2006 Jul;48(1):4-8.
Mechanism of Actions and Clinical Applications of Proton Pump Inhibitors
- Affiliations
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- 1Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Korea. seolsymd@hanmail.net
Abstract
- Proton pump inhibitors (PPIs) are widely used in clinical practice from early 1990s for the treatment of acid- related diseases. PPIs are superior to histamine2-receptor antagonists or anticholinergic agents. These drugs have proven to be effective, safe and well-tolerated during the past two decades. This brief review presents the pharmacodynamics and pharmacokinetics of PPIs and presents clincal applications of the drugs in acid-related diseases.