Korean J Gastroenterol.  2006 Jul;48(1):4-8.

Mechanism of Actions and Clinical Applications of Proton Pump Inhibitors

Affiliations
  • 1Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Korea. seolsymd@hanmail.net

Abstract

Proton pump inhibitors (PPIs) are widely used in clinical practice from early 1990s for the treatment of acid- related diseases. PPIs are superior to histamine2-receptor antagonists or anticholinergic agents. These drugs have proven to be effective, safe and well-tolerated during the past two decades. This brief review presents the pharmacodynamics and pharmacokinetics of PPIs and presents clincal applications of the drugs in acid-related diseases.

Keyword

Proton pump inhibitors; Action mechanism; Clinical application; Acid-related diseases

MeSH Terms

Gastric Acid/*secretion
Gastrointestinal Agents/pharmacokinetics/*pharmacology/therapeutic use
Humans
Proton Pumps/*antagonists & inhibitors
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