Korean J Intern Med.  2003 Dec;18(4):260-265.

A Typical Korean Case Of Carney Complex

• Yoon HD
• Shon HS

Abstract

Carney complex is a multiple neoplasia syndrome, inherited in an autosomal dominant manner, that is characterized by lentigines, cardiac myxoma, and numerous endocrine and other tumors, including primary pigmented nodular adrenocortical disease. Here, we describe a typical case of Carney complex in a 27- year-old female who exhibited spotty skin pigmentation on the lips, oral mucosa, fingers, and toes and several manifestations of Cushing's syndrome due to primary pigmented nodular adrenocortical disease. She also had pituitary adenoma, breast tumor and thyroid nodule. Only a few cases of this disorder have been reported in the Korean literature. All of them, however, had only two components of Carney complex: composed of skin pigmentation and primary pigmented nodular adrenocortical disease. Therefore, the present case seems to be the first true case of Carney complex reported in Korea.

Keyword

Multiple primary neoplasms; Adrenal cortex neoplasm; Cushing syndrome

MeSH Terms

Adult
Cushing Syndrome/*diagnosis
Female
Human
Hyperpigmentation/diagnosis
Magnetic Resonance Imaging
Multiple Endocrine Neoplasia/diagnosis
Myxoma/*diagnosis/genetics
Neoplasms, Multiple Primary/*diagnosis
Pituitary Neoplasms/*diagnosis
Skin Neoplasms/*diagnosis/genetics
Syndrome