Korean J Intern Med.  2003 Mar;18(1):40-44.

Primary non-Hodgkin's Lymphoma of the Bladder with Bone Marrow Involvement

• Oh KC
• Zang DY

Abstract

Involvement of the lower urinary tract by advanced non-Hodgkin's lymphoma (NHL) has been reported in up to 13% of cases, but primary NHL of the urinary bladder is very rare. A 35-year-old man was admitted to our hospital with a chief complaint of gross hematuria with left flank pain on April 12, 2001. Cystoscopy revealed an edematous broad-based mass on the left lateral wall of the bladder, and transurethral biopsy showed NHL, diffuse large B-cell type. Abdomino-pelvic CT scan demonstrated left-side hydronephrosis and hydroureter with left proximal ureter infiltration and thickening of the left lateral wall of the bladder with perivesical fat infiltration without lymph node enlargement. Full-scale staging work-up revealed the bone marrow as the solely involved site. The lesions of the bladder and left urinary tract were nearly completely regressed after two cycles of systemic cyclophosphamide, doxorubicin, vincristine and predinisone (CHOP) chemotherapy with simultaneous restoration of urinary function.

Keyword

Lymphoma; Non-Hodgkin; Bladder; Bone Marrow

MeSH Terms

Adult
Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
Biopsy, Needle
Bone Marrow/*pathology
Bone Neoplasms/pathology/*secondary
Cyclophosphamide/*administration & dosage
Cystoscopy
Doxorubicin/*administration & dosage
Follow-Up Studies
Humans
Immunohistochemistry
Lymphoma, Non-Hodgkin/drug therapy/*pathology
Male
Neoplasm Staging
Prednisone/*administration & dosage
Tomography, X-Ray Computed
Treatment Outcome
Urinary Bladder Neoplasms/drug therapy/*pathology
Urodynamics
Vincristine/*administration & dosage