Yonsei Med J.  2000 Jun;41(3):407-410. 10.3349/ymj.2000.41.3.407.

A case of membranoproliferative glomerulonephritis associated with a hydatidiform mole

• Han BG
• Kim MH
• Karl EH
• Hong SW
• Choi SO

• KMID: 711767
• DOI: http://doi.org/10.3349/ymj.2000.41.3.407

Abstract

We treated a 54-year-old woman who was suffering from membranoproliferative glomerulonephritis associated with a complete type of hydatidiform mole. The renal manifestations were proteinuria and hematuria. A renal biopsy, performed before gynecologic management, disclosed focal and segmental subendothelial deposits with a proliferation of the mesangial cell and showed irregularly thickened capillary loops by light and electronmicroscoy. Genralized edema, proteinuria and hematuria were completely recovered by suction and curettage of the hydatidiform mole with prophylactic chemotherapy. The clinical manifestation of earlier presented 3 cases have been the nephrotic syndrome. The common feature of them was a complete remission of the nephropathy after the removal of the hydatidiform mole. The relationship between the hydatidiform mole and glomerulonephritis remains unresolved at present. But we concluded that the hydatidiform mole might be a cause of glomerulonephritis in this case.

Keyword

Glomerulonephritis; hydatidiform mole

MeSH Terms

Case Report
Diagnosis, Differential
Edema/etiology
Female
Glomerulonephritis, Membranoproliferative/pathology
Glomerulonephritis, Membranoproliferative/etiology*
Hematuria/etiology
Human
Hydatidiform Mole/therapy
Hydatidiform Mole/diagnosis*
Hydatidiform Mole/complications*
Middle Age
Pregnancy
Proteinuria/etiology
Uterine Neoplasms/therapy
Uterine Neoplasms/diagnosis*
Uterine Neoplasms/complications*