Yonsei Med J.
1998 Oct;39(5):453-462. 10.3349/ymj.1998.39.5.453.
Morphologic studies of the retina in a new diabetic model; SHR/N:Mcc-cp rat
- Affiliations
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- 1Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
- 2Department of Food Science and Technology, The Ohio State University, Columus, Ohio, U.S.A..
- 3Department of Ophthalmology, The Ohio State University, Columus, Ohio, U.S.A..
- KMID: 711583
- DOI: http://doi.org/10.3349/ymj.1998.39.5.453
Abstract
- The pathogenesis of diabetic retinopathy has not been fully explained. The earliest histological lesion is the loss of intramural pericytes and thickening of the basement membrane. Increased activity of the polyol pathway is a probable mechanism for these two abnormalities. Investigations have suffered from the lack of an exact animal model simulating the human condition. Examination of the retina in the spontaneously diabetic SHR/N:Mcc-cp rat demonstrated degeneration and loss of intramural pericytes, a progressive increase in basement membrane thickness, and microinfarctions with an area of non-perfusion. Therefore, this model may be used to clarify the biochemical mechanisms linking the metabolic abnormalities of diabetes and retinopathy.
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