J Korean Med Sci.  2000 Apr;15(2):229-232. 10.3346/jkms.2000.15.2.229.

Extranasal T/NK-cell lymphoma presenting as intestinal diverticulum

• Lee YS
• Kang CS
• Kim BK
• Shim SI

• KMID: 648129
• DOI: http://doi.org/10.3346/jkms.2000.15.2.229

Abstract

A case of intestinal angiocentric T/NK-cell lymphoma in a 58-year-old man is reported. The patient presented initially with panperitonitis because of perforation of sigmoid colon diverticulum. He underwent segmentectomy of involved bowel. Histologically, the intestinal wall showed diffuse infiltration of medium or large size lymphoma cells with angiocentric growth and necrosis. The lymphoma cells were CD56+, CD45RO+, CD3+, CD4-, CD8-, CD20-, and CD30- in paraffin sections with germline configuration of TCR-gamma gene, consistent with T/NK-cell lymphoma. Further staging revealed splenomegaly. Intestinal angiocentric T/NK cell lymphoma represents a distinct etiology of diverticulum with perforation.

Keyword

Lymphoma, T/NK-Cell; Neoplasms,Sigmoid; Gastrointestinal Neoplasms; Diverticulum

MeSH Terms

Antigens, CD56/analysis
Case Report
Colon/pathology*
Colonic Neoplasms/radiography
Colonic Neoplasms/pathology*
DNA, Neoplasm/analysis
Diagnosis, Differential
Diverticulitis, Colonic/radiography
Diverticulitis, Colonic/pathology*
Human
Immunoglobulins, Heavy-Chain/genetics
Killer Cells, Natural/pathology*
Killer Cells, Natural/chemistry
Lymphoma, T-Cell/pathology*
Lymphoma, T-Cell/chemistry
Male
Middle Age
Necrosis
Peritonitis/radiography
Peritonitis/pathology
Receptors, Antigen, T-Cell/genetics
Tomography, X-Ray Computed