J Korean Med Sci.  1995 Apr;10(2):103-110. 10.3346/jkms.1995.10.2.103.

Malignant inverted papilloma of the urinary bladder: the histopathological aspect of malignant potential of inverted papilloma

• Cheon J
• Kim HK
• Kim JJ
• Yoon DK
• Koh SK
• Kim IS

• KMID: 644862
• DOI: http://doi.org/10.3346/jkms.1995.10.2.103

Abstract

To investigate the histopathological characteristics of inverted papillomas of the urinary bladder, including the possibility of malignant transformation, we studied the indicators of cellular proliferation activity in 7 inverted papillomas of the bladder including two cases of malignant inverted papilloma of the bladder. PCNA expression rates in two cases of malignant inverted papilloma were higher than in benign inverted papillomas. Mean numbers of AgNORs per nucleus in malignant inverted papillomas were much more than in benign inverted papillomas. The c-erbB-2 oncoprotein was expressed only in malignant inverted papillomas. These results suggest that PCNA expression rate, mean number of AgNORs per nucleus and c-erB-2 oncoprotein expression may be merited as good indicators to detect the inverted papilloma with more proliferative and aggressive lesions, and with the potential of malignant transformation.

MeSH Terms

Adult
Bladder Diseases/pathology
Bladder Neoplasms/chemistry/*pathology
Cell Division/physiology
Cell Transformation, Neoplastic/pathology
Female
Human
Male
Middle Age
Nitrosourea Compounds/analysis
Nucleolus Organizer Region/chemistry
Papilloma, Inverted/chemistry/*pathology
Receptor, erbB-2/analysis
Silver Staining