J Wound Manag Res.  2025 Oct;21(3):115-126. 10.22467/jwmr.2025.03321.

Exploring the Role of Gelatins in Accelerating Wound Healing: A Recent Update

• Cahyadi S
• Djawad K
• Widita W
• Wahab S
• Fitriani Azis NR

• KMID: 2573310
• DOI: http://doi.org/10.22467/jwmr.2025.03321

Abstract

The biological properties of gelatin have gained considerable attention in wound repair due to its ability to support essential cellular activities. As a derivative of collagen, gelatin is a vital component of the extracellular matrix, providing structural integrity to tissues. Its biodegradability and biocompatibility make it an excellent scaffold that fosters cellular migration and proliferation during the healing process. Gelatinbased materials have emerged as important tools in various clinical applications, particularly for wound management. They promote cell adhesion and migration, critical factors for effective wound healing. Ongoing research into gelatin-based dressings highlights their potential to improve healing outcomes. This review discusses advanced therapeutic strategies, the unique characteristics of gelatin, and its clinical applications in skin wound closure. Furthermore, recent advances in skin regeneration involve gelatin-based scaffolds activated by growth factors and bioactive compounds, offering opportunities for customized therapeutic design.

Keyword

Collagen; Gelatin; Wound healing