Clin Exp Reprod Med.  2025 Sep;52(3):189-201. 10.5653/cerm.2024.07248.

Recent trends in polycystic ovary syndrome treatment based on adult stem cell therapies

• Park H
• Han JW
• Kim GJ

• KMID: 2571344
• DOI: http://doi.org/10.5653/cerm.2024.07248

Abstract

Adult stem cell therapy has emerged as a prominent area of interest in regenerative medicine, drawing attention from numerous researchers who are investigating its potential for treating degenerative diseases, especially those affecting the reproductive system. Despite the growing focus, critical elements such as the optimization of treatment parameters (e.g., transplantation [Tx] route, cell dosage) and enhancement of therapeutic efficacy are still areas of uncertainty. This review paper presents a thorough analysis of recent preclinical and clinical studies on adult stem cell therapy for ovarian dysfunction, specifically targeting conditions like polycystic ovary syndrome (PCOS). By examining these studies, the review seeks to clarify the current state of knowledge and pinpoint gaps in understanding, thereby establishing a robust foundation for future advancements in adult stem cell therapies aimed at ovarian dysfunction. Ultimately, this paper aims to offer valuable insights that could lead to improved treatment strategies in the field of reproductive system diseases.

Keyword

Adult stem cell therapy; Mesenchymal stem cell therapy; Optimized treatment; Ovarian dysfunction; Polycystic ovary syndrome; Therapeutic effect