J Med Life Sci.
2025 May;22(2):53-59. 10.22730/jmls.2025.22.2.53.
The effect of uric acid-lowering therapy on vascular stiffness in patients with gout
- Affiliations
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- 1Department of Internal Medicine, Jeju National University Hospital, Jeju National University College of Medicine, Jeju, Republic of Korea
- KMID: 2568127
- DOI: http://doi.org/10.22730/jmls.2025.22.2.53
Abstract
- Several studies have reported that vascular stiffness and risk of cardiovascular disease increase in patients with gout. Although it has been reported that uric acid-lowering treatment improves vascular stiffness in several patient groups, it remains unclear whether uric acid-lowering treatment improves vascular stiffness in patients with gout. Therefore, this study aimed to determine whether vascular stiffness improves by measuring the augmentation index along with uric acid-lowering treatment for 2 years in patients with gout. This study showed that vascular stiffness improved in 67% of the patients, and patients with high initial vascular stiffness showed better improvement in vascular stiffness after uric acid-lowering treatment. Regression analysis was performed to identify factors that improved vascular stiffness; however, no factors that improved vascular stiffness were found. Among patients who had already received uric acid-lowering treatment for more than 2 years before starting augmentation index measurements, 67.7% showed improvement in vascular stiffness. Therefore, it is believed that uric acid-lowering treatment in patients with gout can improve vascular stiffness, and if uric acid-lowering treatment is continued, improvement in vascular stiffness is expected to occur gradually over a long period of time.
