J Korean Ophthalmol Soc.  2025 Apr;66(4):181-190. 10.3341/jkos.2025.66.4.181.

Effect of Wearing Phospholipid-releasing Contact Lenses on Dry Eyes in Rabbits

• Kim HJ
• Park S
• Ryu YK
• Hwang JS
• Oh SH
• Lee JH
• Kim GB
• Shin YJ

• KMID: 2566800
• DOI: http://doi.org/10.3341/jkos.2025.66.4.181

Abstract

Purpose
To investigate whether a new phospholipid-releasing soft contact lens can improve symptoms of dry eyes.
Methods
The study used 2.5-3.0 kg New Zealand rabbits including both normal non-dry eye rabbits and dry eye rabbits, the latter having undergone electrocauterization of the meibomian glands to block the gland orifices. Each rabbit wore a control contact lens on one eye and a phospholipid-releasing contact lens on the other eye daily. Phospholipid-releasing and control contact lenses were provided by NEOVISION Co., Ltd. The parameters assessed included tear film break-up time, tear osmolarity, ocular surface staining, and central corneal thickness. After the experiment, the rabbits were euthanized and their conjunctival tissue was stained with Periodic Acid Schiff (PAS) to observe conjunctival goblet cells.
Results
In both dry eye and normal non-dry eye rabbits, tear film break-up time was longer and tear osmolarity was lower when using the phospholipid-releasing contact lens compared to the control contact lens. The ocular surface remained unstained in normal non-dry eye rabbits while staining was observed in dry eye rabbits. There was no significant difference in central corneal thickness between the control and phospholipid-releasing contact lenses in either group. PAS staining showed no difference in conjunctival goblet cell density between the two lens types in normal non-dry eye rabbits. However, in dry eye rabbits, the conjunctival goblet cell density tended to be slightly higher with the phospholipid-releasing contact lens compared to the control lens.
Conclusions
Phospholipid-releasing contact lenses may help reduce dry eye symptoms and minimize contact lens-related complications by stabilizing the tear film and lowering tear osmolarity.

Keyword

Contact lens, Dry eye, Phospholipid, Tears