Korean J Geriatr Gerontol.  2020 Dec;21(2):94-102. 10.15656/kjcg.2020.21.2.94.

Associations among Coronary Artery Calcium Score, Left Ventricular Mass Index and Septal E/E’ Ratio in Subjects with Normal Left Ventricular Ejection Fraction

• Jeon U
• Park SH

• KMID: 2566435
• DOI: http://doi.org/10.15656/kjcg.2020.21.2.94

Abstract

Background
The objective of this study is to determine if associations among the coronary artery calcium (CAC) score (CACS), left ventricular mass index (LVMI), and septal E/E’ ratio.
Methods
We investigated 1230 consecutive subjects with a normal left ventricular ejection fraction who underwent multidetector computed tomography and echocardiography. The CACS was measured using the Agatstone method. Participants were classified as follows, in a two-fold manner: first, negative CAC (CACS=0) group and positive CAC (CACS ＞0) group; second, no (CACS=0), mild (1-100), moderate (101-400), and severe CAC deposits (＞400).
Results
In multivariate binary logistic regression adjusted for covariates, the LVMI and septal E/E’ ratio were independent pre- dictors of positive CAC deposits (CACS ＞0) and severe CACS (CACS ＞400). Regarding the “composite score” based on a septal E/E’ ratio ≥15 and LVMI ≥90 g/m 2 , a higher score was associated with a greater CACS. Per the severity criteria of the CACS, severe CAC deposits were significantly associated with “composite score 2” group and the odds ratios in each group were 1.790, 2.126, and 5.705, respectively.
Conclusion
In our study, the LVMI and septal E/E’ ratio were associated with the CACS, independent of classic risk factors in patients with chest pain or without symptoms with a normal left ventricular ejection fraction.

Keyword

Calcium; Coronary; Echocardiography; Multidetector computed tomography