Korean Circ J.  2025 Mar;55(3):248-250. 10.4070/kcj.2024.0424.

Epigenetic Modulation in Heart Failure: HDAC Inhibitors as Emerging Therapeutic Allies

Affiliations
  • 1Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea


Reference

1. Youn JC, Kim D, Cho JY, et al. Korean Society of Heart Failure guidelines for the management of heart failure: treatment. Int J Heart Fail. 2023; 5:66–81. PMID: 37180564.
Article
2. Lee CJ, Lee H, Yoon M, et al. Heart failure statistics 2024 update: a report from the Korean Society of Heart Failure. Int J Heart Fail. 2024; 6:56–69. PMID: 38694933.
Article
3. McClure JJ, Li X, Chou CJ. Advances and challenges of HDAC inhibitors in cancer therapeutics. Adv Cancer Res. 2018; 138:183–211. PMID: 29551127.
Article
4. Li P, Ge J, Li H. Lysine acetyltransferases and lysine deacetylases as targets for cardiovascular disease. Nat Rev Cardiol. 2020; 17:96–115. PMID: 31350538.
5. Zhou H, Kee HJ, Wan L, et al. YAK577 attenuates cardiac remodeling and fibrosis in isoproterenol-infused heart failure mice by downregulating MMP12. Korean Circ J. 2025; 55:231–247. PMID: 39601396.
Article
6. Yang F, Zhao N, Ge D, Chen Y. Next-generation of selective histone deacetylase inhibitors. RSC Advances. 2019; 9:19571–19583. PMID: 35519364.
Article
7. Yoon S, Eom GH. HDAC and HDAC inhibitor: from cancer to cardiovascular diseases. Chonnam Med J. 2016; 52:1–11. PMID: 26865995.
Article
8. Ho JSY, Jou E, Khong PL, Foo RSY, Sia CH. Epigenetics in heart failure. Int J Mol Sci. 2024; 25:12010. PMID: 39596076.
9. Bagchi RA, Weeks KL. Histone deacetylases in cardiovascular and metabolic diseases. J Mol Cell Cardiol. 2019; 130:151–159. PMID: 30978343.
Article
10. Zhao T, Kee HJ, Kee SJ, Jeong MH. Hdac8 inhibitor alleviates transverse aortic constriction-induced heart failure in mice by downregulating Ace1. Oxid Med Cell Longev. 2022; 2022:6227330. PMID: 35126818.
Article
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