J Gynecol Oncol.
2025 Jan;36(1):e71. 10.3802/jgo.2025.36.e71.
Clinical practice guidelines for uterine corpus cancer: an update to the Korean Society of Gynecologic Oncology guidelines
- Affiliations
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- 1Department of Obstetrics and Gynecology, School of Medicine Kyung Hee University, Kyung Hee University Medical Center, Seoul, Korea
- 2Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
- 3Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea
- 4Department of Obstetrics and Gynecology, School of Medicine, Kangwon National University, Chuncheon, Korea
- 5Comprehensive Gynecologic Cancer Center, CHA Bundang Medical Center, College of Medicine, CHA University, Seongnam, Korea
- 6Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea
- 7Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea
- KMID: 2565504
- DOI: http://doi.org/10.3802/jgo.2025.36.e71
Abstract
- The Korean Society of Gynecologic Oncology has updated its clinical practice guidelines for endometrial cancer to incorporate advancements in recent high-quality randomized controlled trials. These guidelines address evolving treatment paradigms, and are tailored to the Korean medical context. Key updates include a strong recommendation for doxorubicin/trabectedin combination therapy in metastatic or recurrent unresectable leiomyosarcoma based on the significant survival benefits demonstrated in a randomized controlled trial. For advanced or recurrent endometrial cancer, immune checkpoint inhibitors combined with chemotherapy have received strong recommendations, owing to their proven efficacy and increased accessibility in Korea. Conditional recommendations were made for combination therapies involving durvalumab and olaparib, reflecting their potential benefits, but acknowledging regulatory and accessibility constraints. These guidelines aim to provide evidence-based, practical strategies to optimize care for patients with endometrial cancer while addressing unmet clinical needs and adapting global advancements to Korea’s healthcare environment.
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