Korean J Otorhinolaryngol-Head Neck Surg.  2025 Feb;68(2):53-57. 10.3342/kjorl-hns.2024.00325.

Surface Functionalization of Three-Dimensional Printed Scaffold for Biomedical Application

• Shin YS

• KMID: 2565001
• DOI: http://doi.org/10.3342/kjorl-hns.2024.00325

Abstract

Three-dimensional (3D) printing is one of the most effective scaffold manufacturing techniques which might revolutionize the realm of tissue engineering and regenerative medicine. The scaffolds, one of the major elements of tissue engineering, along with growth factors and cells, are still one of the most promising approaches for developing organ regeneration. However, the applications of 3D-printed hard scaffolds might have limitations due to their poor surface properties, which play a crucial role in cell recruitment and infiltration, tissue-scaffold integration, and anti-inflammatory properties. Various prerequisites have been suggested for clinical applications of 3D-printed substitute for human body. Consequently, continuous amendment has been made to modify the surface properties, porosities and mechanical properties of these scaffolds. The techniques that modify the surfaces through chemical and material modifications can also be applied to facilitate the efficacy of these scaffolds. In this review, we summarized the characteristics of 3D printing technology and discuss the development direction of the latest 3D printing technology toward meeting the unmet needs in the clinic.

Keyword

Biomedical application; Surface functionalization; 3D printing