J Gynecol Oncol.  2024 Nov;35(6):e100. 10.3802/jgo.2024.35.e100.

Efficacy and safety of combined anlotinib-oral etoposide treatment for patients with platinum-resistant ovarian cancer

• Huang S
• Sheng G
• Lv Q
• Li Y
• Meng Q
• Gao X
• Shang Z

• KMID: 2564958
• DOI: http://doi.org/10.3802/jgo.2024.35.e100

Abstract

Objective
Despite the availability of numerous treatment options, managing patients with platinum-resistant ovarian cancer (PROC) remains challenging, and the prognosis of PROC is notably unfavorable. This retrospective study aimed to assess the efficacy and safety of combined anlotinib-oral etoposide treatment for patients with PROC.
Methods
Data of 23 patients who were diagnosed with PROC from January 2020 to November 2022 and treated with anlotinib combined with oral etoposide for at least 2 cycles were retrospectively analyzed.
Results
Among per-protocol patients, 9 (45.0%; 95% confidence interval [CI]=21.1–68.9) of 20 patients achieved partial response and 17 (85.0%, 95% CI=67.9–100.0) of 20 patients achieved disease control. The median progression-free survival was 8.7 months (95% CI=5.3–11.6). The incidence of adverse events (any grade) was 100%, and the incidence of grade 3–4 adverse events was 54.5%.
Conclusion
Anlotinib combined with etoposide emerged effective for the treatment of PROC.

Keyword

Anlotinib; Etoposide; Ovarian Neoplasms; Treatment Outcome; Safety