J Korean Ophthalmol Soc.  2025 Feb;66(2):139-144. 10.3341/jkos.2025.66.2.139.

Anterior Displacement of Lens-iris Diaphragm Associated with Vogt–Koyanagi–Harada Disease: A Case Report

• Chae SB
• Kim DG
• Kim JL

• KMID: 2564941
• DOI: http://doi.org/10.3341/jkos.2025.66.2.139

Abstract

Purpose
We present a case of anterior displacement of the lens-iris diaphragm associated with Vogt–Koyanagi–Harada (VKH) disease.
Case summary
A 35-year-old woman presented with decreased vision in her right eye. Examination revealed corrected visual acuity of 0.6 in the right eye and 1.0 in the left eye. Intraocular pressure (IOP) was 14 and 16 mmHg in the right and left eye, respectively. Spherical equivalent (SE) was -17.25 D in the right eye and -9.75 D in the left eye. Slit lamp examination and three-dimensional anterior segment photography revealed anterior displacement of the lens-iris diaphragm in both eyes. Two days later, the left eye developed similar symptoms with an SE of -15.5 D. Fundus examination revealed serous retinal detachment and fluorescein fundus photography demonstrated focal leakage leading to the diagnosis of atypical VKH disease. The patient was treated with oral corticosteroids and her symptoms resolved after 3 weeks. The Final SE was -10.25 D in the right eye and -9.75 D in the left eye.
Conclusions
We suggest there is an association between atypical VKH and anterior lens-iris diaphragm displacement in the absence of elevated IOP; early myopic shift may be associated with this presentation. Therefore, patients with isolated lens-iris diaphragm displacement, particularly those without a history of medications should be monitored for the possibility of developing VKH disease.

Keyword

Angle closure glaucoma, Panuveitis, Vogt-Koyanagi-Harada disease