J Gynecol Oncol.  2024 Jul;35(4):e41. 10.3802/jgo.2024.35.e41.

Cerebral infarction caused by Trousseau syndrome associated with cervical cancer

• Kanno M
• Yunokawa M
• Fusegi A
• Abe A
• Nomura H
• Kanao H

• KMID: 2564918
• DOI: http://doi.org/10.3802/jgo.2024.35.e41

Abstract

Objective
The combination of cancer and hypercoagulable states is often called Trousseau syndrome. In particular, cerebral infarction caused by Trousseau syndrome is reported to have a poor prognosis. In gynecology, there are many reports of ovarian cancer and a few of uterine cancer. Since there has been no comprehensive report of Trousseau syndrome in cervical cancer, we aimed to summarize Trousseau syndrome in cervical cancer.
Methods
Cerebral infarction caused by cancer-related arterial thrombosis was defined as Trousseau syndrome. Patients with cervical cancer diagnosed at our hospital between January 2014 and December 2021 were retrospectively reviewed using the hospital’s medical records.
Results
A total of 1,432 patients were included in the study. Trousseau syndrome occurred in 6 patients (0.4%). The mean age of patients with Trousseau syndrome was 63 years (range: 53–78 years). Of the 6 patients who developed Trousseau’s syndrome, 4 patients had it before or during initial treatment, and 2 during recurrent/relapsed disease treatment. The 4 patients who developed the syndrome before or during initial treatment had advanced disease: 1 in stage IIIC and 3 in stage IVB. In all cases, the disease was associated with progressive distant metastasis. The median survival time from the onset of Trousseau syndrome was 1 month (range: 0–6 months).
Conclusion
Cervical cancer causes Trousseau syndrome in cases of advanced disease with a short time between the onset of the syndrome and mortality.

Keyword

Cervical Cancer; Cerebral Infarction; Thromboembolism; Lymph Node Metastasis; Tissue Factor