Korean J Psychosom Med.  2024 Dec;32(2):77-86. 10.22722/KJPM.2024.32.2.77.

Association Between Psychotic Symptoms of Mood Disorders and Hematologic Findings Related to Inflammation: A Retrospective Study

• Oh YS
• Im WY
• Shin SH
• Lee JC
• Kim JW
• Kim SJ
• Lee NH
• Oh HS

• KMID: 2564521
• DOI: http://doi.org/10.22722/KJPM.2024.32.2.77

Abstract

Objectives
：This study was aimed to determine whether the presence or absence of psychotic symptoms in mood disorders is statistically significantly related to the difference between NLR, MLR, PLR.
Methods
：We retrospectively reviewed the medical records of 408 patients who were hospitalized with a diagnosis of bipolar disorder type 1 (BP-I) and major depressive disorder (MDD) and underwent complete blood count. Groups were divided based on the presence or absence of psychotic symptoms. The statistical significance of the differences in NLR, MLR, and PLR between each group was examined using t-test.
Results
：When 382 mood disorder patients were divided into groups based solely on the presence or absence of psychotic symptoms, the difference between NLR and MLR was statistically significant (NLR: p=0.009, MLR: p=0.016). When dividing the mood disorder patients into subgroups of 176 BP-I patients and 206 MDD patients and using the same method for each subgroup, the tendency for higher NLR and MLR was maintained, but the sta-tistical significance disappeared.
Conclusions
：This study suggests the possibility of relationship between psychotic symptoms and NLR and MLR in mood disorders, but additional research appears to be necessary to clarify the possibility.

Keyword

Mood disorders; Psychotic features; Neutrophil-to-lymphocyte ratio; Monocyte-to-lymphocyte ratio