J Korean Acad Child Adolesc Psychiatry.
2025 Jan;36(1):18-25. 10.5765/jkacap.240035.
Association Between Endocrine-Disrupting Chemicals Exposure and Attention-Deficit/Hyperactivity Disorder Symptoms in Children With Attention-Deficit/ Hyperactivity Disorder
- Affiliations
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- 1Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
- 2Department of Psychiatry, Seoul National University Hospital, Seoul, Korea
- 3Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea
- 4Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University Hospital, Seoul, Korea
- 5Department of Psychiatry, Hanyang University College of Medicine, Seoul, Korea
- KMID: 2564106
- DOI: http://doi.org/10.5765/jkacap.240035
Abstract
Objectives
This study investigated the relationship between exposure to endocrine-disrupting chemicals (EDCs), specifically phthalates, bisphenol A, bisphenol F, and bisphenol S, and the severity of attention-deficit/hyperactivity disorder (ADHD) symptoms using neuropsychological tests in children diagnosed with ADHD.
Methods
This study included 67 medication-naïve children with ADHD aged 6–16 years. The urinary concentrations of EDCs were measured, and ADHD symptom severity was evaluated using neuropsychological tests and clinical symptom scale measurements. The Jonckheere–Terpstra test, Pearson and Spearman correlation analyses, linear regression models, and multiple regression models were used to examine the relationship between EDC exposure and ADHD symptoms.
Results
A significant correlation was observed between urinary phthalate metabolite concentrations and commission error T-scores in the visual Advanced Test of Attention test. No significant associations were found with other neuropsychological indicators or bisphenol levels.
Conclusion
Phthalate exposure affects impulsivity in children with ADHD, which is consistent with the results of previous studies that used parental surveys. However, bisphenols are not clearly associated with ADHD symptoms, which is consistent with the results of previous studies.
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