Res Vestib Sci.
2024 Sep;23(3):101-105. 10.21790/rvs.2024.015.
Saccadic oscillations as a possible indicator of dizziness due to choline esterase inhibitors: an observational study with video-oculography
- Affiliations
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- 1Department of Neurology, Konkuk University Medical Center, Seoul, Korea
- 2Department of Neurology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea
- 3Dizziness Center, Clinical Neuroscience Center, and Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Korea
- 4Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea
- KMID: 2563703
- DOI: http://doi.org/10.21790/rvs.2024.015
Abstract
- Introduction
Cholinesterase inhibitors (ChEIs) are widely used to treat mild to moderate Alzheimer disease and vascular dementia. Even though dizziness due to medication of ChEIs has been ascribed to adverse effects on the cardiovascular or central nervous system, the mechanisms remain unclear and objective indicators are not available.
Methods
We recorded the eye movements using video-oculography in three patients who developed dizziness and unsteadiness after initiation or increment of ChEI, donepezil (Aricept).
Results
The patients showed frequent saccadic oscillations that improved after discontinuation of ChEI.
Conclusions
Frequent saccadic oscillations may be an indicator of dizziness in patients taking ChEIs.
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