J Mycol Infect.  2024 Sep;29(3):170-174. 10.17966/JMI.2024.29.3.170.

Diagnostic Challenges of Mucormycosis in a Patient with Diabetes: A Case Report

• Putra ND
• Anggraeni S
• Ervianti E
• Astari L
• Widia Y

• KMID: 2563179
• DOI: http://doi.org/10.17966/JMI.2024.29.3.170

Abstract

Mucormycosis is a rare and life-threatening fungal infection that predominantly affects immunocompromised individuals, particularly those with poorly controlled diabetes mellitus. Achieving an accurate diagnosis remains a significant challenge in clinical practice. We report a case of mucormycosis in a 25-year-old woman who presented with an altered mental status and a 5 × 2 cm necrotic lesion on the left nasal septum, characterized by indistinct borders, during admission. Prolonged diagnostic investigations ultimately led to the identification of nasal mucormycosis attributable to Rhizomucor pusillus, a rare species within the Mucorales order, which complicates the diagnostic process. Unfortunately, the patient's clinical condition rapidly deteriorated, resulting in her demise prior to the administration of systemic antifungal therapy. Although the comprehensive evaluations facilitated the identification of the causative agent, the time required for this process did not favor the patient's prognosis. The atypical symptoms, swift progression, and infrequent occurrence of mucormycosis underscore the critical importance of its timely and accurate diagnosis to ensure favorable patient outcomes. Proper identification of the pathogen and immediate administration of therapeutic interventions can considerably enhance the likelihood of patient recovery and survival.

Keyword

Deep mycosisv; Diabetes mellitus; Mucormycosis; Rhizomucor