Precis Future Med.  2024 Dec;8(4):137-155. 10.23838/pfm.2024.00121.

Bibliometric analysis of literature on stem cells in regenerative medicine and their clinical applications (2010 to 2024): A scoping review

• Nurbaeva MK
• Dzhunushalieva G

• KMID: 2562863
• DOI: http://doi.org/10.23838/pfm.2024.00121

Abstract

Stem cells in regenerative medicine are advancing rapidly, with significant progress made in recent years. Our bibliometric review is a significant contribution to the field and is essential for advancing research. However, there is a noticeable lack of reviews that focus on stem cells and their clinical applications in regenerative medicine. Our study addressed this gap using advanced tools such as R-Studio and VOSviewer to explore publication volumes, intellectual structures, and emerging trends in the field, ensuring the validity and reliability of our findings. We utilized Scopus and Web of Science to extract 1,274 relevant articles and employed rigorous descriptive analysis, co-occurrence analysis, and text-mining techniques. Our study identified the most influential journals based on productivity and citation volume. These journals are: International Journal of Molecular Sciences, Stem Cell Reviews and Reports, Biomaterials, Stem Cell Research and Therapy, Regenerative Therapy, Stem Cells Translational Medicine, and Cytotherapy. The top-cited articles highlight mRNA, stem cell reprogramming, and innovative therapeutic techniques. Our analysis of the links between stem cells and disease underscores the significant focus on mesenchymal stem cells and pluripotent stem cells, with the most frequently treated conditions being knee osteoarthritis, various types of cancer, and cardiovascular diseases. We also identified emerging areas classified as materials, methods, and technologies such as biopolymers, nanotechnology, deep learning, Kyoto Encyclopedia of Genes and Genomes, three-dimensional printers, and bioprinting. By investigating this focused area, this study provides valuable insights into the current landscape and future directions of stem cell-based regenerative medicine with a clear clinical translation pathway.

Keyword

Bibliometrics; Clinical trial; Regenerative medicine; Stem cells; VOSviewer