J Korean Burn Soc.  2024 Dec;27(2):7-13. 10.47955/jkbs.24.0003.

Use of Cytokine Adsorbers for Sepsis in Patients with Burns

• Turan G
• Ozcan FG
• Turan M
• Bozkurt B
• Yurt S
• Altuntas O
• Yiyit N

• KMID: 2562446
• DOI: http://doi.org/10.47955/jkbs.24.0003

Abstract

In patients who have severe burn injuries with a large surface area, inflammatory response of the immune system, which is subsequently followed by anti-inflammatory response, results in immune dysregulation and this makes burn victims vulnerable to infection. With the disruption of skin integrity, the body becomes vulnerable to infection. Thermal injury disrupts cellular integrity, and eschar forms over the wound bed. Successive escharotomy procedures performed as part of treatment also lead to increased susceptibility to infection. The cytokine adsorber is a treatment modality that can be useful in preventing the transition to infection by removing inflammatory mediators from the blood. In our case series, we wanted to present the patients who were followed up for a prolonged period in our hospital’s burn intensive care clinic due to 75~90% 4th degree burns as a result of an explosion in a coal mine and periodically received cytokine adsorbents.

Keyword

Sepsis; Cytokine adsorber; Burn; ICU