Clin Psychopharmacol Neurosci.
2024 Nov;22(4):578-584. 10.9758/cpn.23.1148.
Ultradian Rest-activity Rhythms Induced by Quinpirole in Mice Using Wavelet Analysis
- Affiliations
-
- 1Department of Psychiatry and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea
- 2Department of Psychiatry, Pusan National University School of Medicine, Yangsan, Korea
- 3Department of Applied Mathematics, Pukyong National University, Busan, Korea
- 4Department of Psychology, Gyeongsang National University, Jinju, Korea
- 5Department of Pediatrics, College of Medicine, Kosin University, Busan, Korea
- KMID: 2562269
- DOI: http://doi.org/10.9758/cpn.23.1148
Abstract
Objective
Ultradian rhythms are biological rhythms with periods of a few seconds to a few hours. Along with circadian rhythms, ultradian rhythms influence human physiology. However, such rhythms have not been studied as intensively as circadian rhythms. This study aimed to identify ultradian rest-activity rhythms induced by the dopamine D2/D3 agonist quinpirole in mice.
Methods
We used 10 mice from the Institute of Cancer Research. Quinpirole was administered at a dose of 0.5 mg/kg. We assessed free rest-activity using infrared detectors and conducted wavelet analysis to measure the period and its variation. We also used the paired t test to compare ultradian rhythm patterns.
Results
Quinpirole did not significantly change total 24-hour locomotor activity (p = 0.065). However, it significantly increased locomotor activity during the dark phase (p = 0.001) and decreased it during the light phase (p = 0.016). In the continuous wavelet transform analysis, the mean period was 5.618 hours before quinpirole injection and 4.523 hours after injection. The period showed a significant decrease (p = 0.040), while the variation remained relatively consistent before and after quinpirole injection.
Conclusion
This study demonstrated ultradian rest-activity rhythms induced by quinpirole using wavelet analysis. Quinpirole-induced ultradian rhythms exhibited rapid oscillations with shortened periods and increased activity during the dark phase. To better understand these changes in ultradian rhythms caused by quinpirole, it is essential to compare them with the effects of other psychopharmacological agents. Furthermore, investigating the pharmacological impact on ultradian rest-activity rhythms may have valuable applications in clinical studies.
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