J Korean Soc Radiol.  2024 Nov;85(6):1200-1208. 10.3348/jksr.2024.0023.

Hyperperfusion Syndrome Following Tissue Plasminogen Activator Administration: A Case Report with Radiological Evidence

Affiliations
  • 1Department of Radiology, Kangwon National University Hospital, Chuncheon, Korea
  • 2Departments of Radiology, College of Medicine, Kangwon National University, Chuncheon, Korea
  • 3Departments of Neurology, College of Medicine, Kangwon National University, Chuncheon, Korea

Abstract

Cerebral hyperperfusion syndrome is a rare complication that can occur following carotid artery revascularization procedures in patients with chronic carotid artery stenosis. Cases of hyperperfusion syndrome resulting solely from intravenous tissue plasminogen activator administration, without a history of revascularization, are extremely rare. Only four of such cases have been reported with imaging evidence. This report presents a case of early neurological deterioration in acute ischemic stroke, identified as a form of hyperperfusion syndrome. Imaging evidence supports this diagnosis, and highlights the occurrence of hyperperfusion syndrome after intravenous tissue plasminogen activator administration.

Keyword

Cerebrovascular Circulation; Perfusion Imaging; Reperfusion Injury; Stroke; Tissue Plasminogen Activator
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