J Cosmet Med.  2023 Jun;7(1):25-28. 10.25056/JCM.2023.7.1.25.

Anti-inflammatory effects of ethanolic extract of Annona muricata

• Shin YM
• Kim YJ

• KMID: 2561173
• DOI: http://doi.org/10.25056/JCM.2023.7.1.25

Abstract

Background
Graviola (Annona muricata) is known to have a superior cancer cell killing effect than adriamycin, a chemical drug, and is used in hospitals. Check to see if it actually has an anti-inflammatory effect on the skin.
Objective
This study was conducted to assess the anti-inflammatory and molecular effects of A. muricata leaf extract to evaluate its potency as a cosmetic ingredient and value in the cosmetic industry.
Methods
The anti-inflammatory effects of A. muricata were evaluated using an ethanolic extract of its dried leaves. To assess the inhibitory effects of A. muricata extract on nitric oxide (NO) production, the amount of NO produced in RAW 264.7 cells induced by lipopolysaccharides (LPS), an inflammatory mediator, was measured.
Results
The experiment using the A. muricata leaf extract did not show a significant level of cytotoxicity at all concentration of the extract, and the survival rate of RAW 264.7 cells was low only at high concentrations of the extract. Assessment of the antiinflammatory effects of A. muricata leaf extract showed that a significant amount of NO production was inhibited in the cells compared to that when the leaf extract was incubated with LPS.
Conclusion
A. muricata leaf extract would be an excellent candidate as a cosmetic ingredient with its anti-inflammatory properties and other functions.

Keyword

Annona muricata; Annona muricata; anti-inflammatory; anti-inflammatory; cosmetic ingredients; cosmetic ingredients; dried graviola leaves; dried graviola leaves; graviola; graviola